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View Full Version : Painkillers inhibit Protein sythesis!



Darkane
08-28-2008, 03:59 PM
Neat little study. I personally never take painkillers for any reason. In fact I don't think I've popped one for over 6 years. It should be interesting come time to get my Wisdom teeth yanked out haha. But anyway;

Aspirin & other Pain Killers’ Effects on Muscle Growth
November 1st, 2007 by Paul Johnson

A few years ago, research started coming out about the effects of common OTC painkillers effects on muscle growth. If you are new to bodybuilding in recent years, you may have missed the big news when it first came out. Many bodybuilders take them to relieve muscle soreness (DOMS) from weight training or some other ailment and don’t know about this side effect. This is also important to know because many fat burning supplements, such as hydroxycut hardcore, put willow bark ( natural form of aspirin ) in it. Acetaminophen ( Tylenol ) and the class of drugs called ( NSAIDS ), which includes the OTC painkillers, ibuprofen (Advil, Motrin) and naproxen ( Alleve ), all have an effect on protein synthesis.

Studies on painkiller effects on protein synthesis:

One of the first studies to come out was published in
J Clin Endocrinol Metab. 2001 Oct;86(10):5067-70. It was done on 24 males to either receive ibuprofen, acetaminophen or a control after resistance excercise workout (10 - 14 sets). It showed that acetaminophen and ibuprofen had an impact on prostoglandins (in equal degree). Researchers concluded this impact on prostoglandins could have a big impact on muscle growth.

One year later, these same researchers published (Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E551-6.) measuring protein synthesis after resistance workout. The study was done on 24 males who either took acetaminophen, ibuprofen, or control. Results showed that the placebo group had 75% higher protein synthesis at the skeletal muscle than the ibuprofen or acetaminophen group. These painkillers didn’t effect overall body breakdown, but did effect protein synthesis at the muscle.

Aspirin also has a effect on decreasing protein synthesis. (source: J Biol Chem. 2007 Apr;282(14):10164-71. Epub 2007 Feb 6.)

Most of the older studies discuss protein synthesis, but a more
recent study published in (Med Sci Sports Exerc. 2006 May;38(5):840-6.) compared overloading a rat muscle with or without ibuprofen on actual muscle growth. Results showed reduced muscle hypertrophy (muscle growth) by 50% in rats from ibuprofen with overload vs. overload only.

As you can see these were not minor changes in protein synthesis. Even occasional use will have a significant impact on muscle growth.

08-28-2008, 04:22 PM
http://i72.photobucket.com/albums/i196/wilast/towelie.jpg

Darkane
08-28-2008, 04:25 PM
Originally posted by [email protected]
http://i72.photobucket.com/albums/i196/wilast/towelie.jpg

Towley<sp> is a homo.

But on a serious note, weed also crashes test levels and brings up Estrogen. That's why people are so "chilled" when high lol.

GTS Jeff
08-28-2008, 10:15 PM
Two studies from the same group of researchers is hardly conclusive evidence. You can make your data support whatever you want, so nothing is accepted until reproduced many times by other researchers.

In this case, I think you are reading into the articles too much. First off, it's prostAglandins, and yes, painkillers affect those because they are key components in the pain/inflammation pathway. The second article indicates that protein synthesis "could" be affected - it's tough to say since their sample size only contains 24 people.

I think the most conventional thinking behind all this is that working out damages your muscles, so that your body creates inflammation around them to repair them. Drugs that inhibit inflammatory processes, would then seem counterproductive. The main ones here would be NSAIDS, or for most people, anything with ASA or ibuprofen (Aspirin, Motrin, Advil, etc.) This is just my uneducated opinion, but I would say that tylenol is safe since it just acts as an analgesic...

FilthyMcNasty
08-29-2008, 02:39 PM
Originally posted by Darkane


Towley&lt;sp&gt; is a homo.

But on a serious note, weed also crashes test levels and brings up Estrogen. That's why people are so &quot;chilled&quot; when high lol.

A new study by Dr. Robert Block at the University of
Iowa disputes the commonly held notion that marijuana alters
the level of testosterone and other sex hormones.
The study contradicted a widely publicized 1974 study
by Dr. R.C. Kolodony, which reported decreased testosterone
levels in men who smoked marijuana chronically.
The U. of Iowa study found that chronic marijuana use
had no effect on testosterone, luteinizing hormone, follicle
stimulating hormone, prolactin and cortisol in men or women.
Noting that six other studies had failed to show
lowered testosterone levels in men, Dr. Block concluded: "It
appears that marijuana, even heavy use of the kind that's
typical in the United States, doesn't alter testosterone levels."
However, he cautioned that heavy use might have other
adverse effects, including "possible effects on reproductive
function and mild, selective cognitive impairments associated
with heavy, chronic use."




I smoke weed everyday my friend, all the time except for when im working, even before and after w/o. I have consistently seen positive results throughout the course of my personal fitness. I simply disagree as my own body is proof of the matter. And i have never used any steroids whatsoever..

420!!

Darkane
08-29-2008, 03:01 PM
^^ Right on. You might be a minority who has gene's to be anabolic in many situations.

Whats your max weight for the big 3, BF%, body weight and height?

This is interesting, based on that info would you be willing to take 6 weeks without pot to see what happens?

EDIT: Also forgot to add, your personal progress is relative. Even with decreased test, gains can be made.

Women can become muscular and make gains.

FilthyMcNasty
08-29-2008, 03:30 PM
^^^


to be honest man i havent done max rep for bench, squat or deadlift(if thats the big 3), maybe i have but i dont remember or record it. i think that doing 1 max rep doesn't do anything for your muscles.

currently by bf is at 8% im 5'7. But hahah theres no way ill stop smoking weed just to see if ill progress faster. Maybe you're right. But fuck it, im happy gettin high and 6 weeks with no smoke would just make me cranky as fuck.

The hardest thing about my lifestyle would be dieting. But before i went to the Dominican i managed to cut down to 4%.. not bad for a stoner..

civic_rida
08-29-2008, 03:44 PM
:bullshit:

you have no idea what 4% looks like .

Darkane
08-29-2008, 03:50 PM
Originally posted by FilthyMcNasty
^^^




currently by bf is at 8% im 5'7. But hahah theres no way ill stop smoking weed just to see if ill progress faster. Maybe you're right. But fuck it, im happy gettin high and 6 weeks with no smoke would just make me cranky as fuck.

The hardest thing about my lifestyle would be dieting. But before i went to the Dominican i managed to cut down to 4%.. not bad for a stoner..

Fair enough. I'm always consciously nagged by my overactive ambitious side, so nothing is really good enough for me. But if you're happy then thats it really. Good on ya.

But yeah, as per the 4% not happening :P

http://www.t-nation.com/free_online_article/sports_body_training_performance_bodybuilding/shredded_in_6_days

Level 4 in that program is about 4-5%. Did you have lower ab vascularity? :rofl:

SteveMo600
08-29-2008, 04:03 PM
Originally posted by FilthyMcNasty
^^^
The hardest thing about my lifestyle would be dieting. But before i went to the Dominican i managed to cut down to 4%.. not bad for a stoner..

I'm with civic_rida, I call huge bullshit on the 4%. A BF level of 4% is pretty much bodybuilder's competition level. That sort of BF level is on the cusp of organ damage.

I'm not going to believe this unless more than a handful are tested, by multiple different specialists. A sample of 24 isn't even close to enough, as the sample could be incredibly skewed with people that have a hard time building muscle, different body response to exercise etc.

bigbadboss101
08-29-2008, 04:40 PM
NSAID and other anti-inflammatory drugs affect protein synthesis?
How about Omega 3's?

I am taking AA in Animal Test and instruction says to not take with fish oil, or any anti-inflammatory drugs, NSAID etc.

civic_rida
08-29-2008, 11:44 PM
im gonna try this get cut in 6 days thing.
Im probably at level 2 right now.

Darkane
08-30-2008, 10:09 AM
Originally posted by civic_rida
im gonna try this get cut in 6 days thing.
Im probably at level 2 right now.

Follow it exactly and it will work. It's VERY important to do the low carb days. In fact if you're cheating those days it won't be nearly as effective.

Take some pics to compare. See what happens.

JAYMEZ
08-30-2008, 11:11 AM
Originally posted by FilthyMcNasty
^^^


to be honest man i havent done max rep for bench, squat or deadlift(if thats the big 3), maybe i have but i dont remember or record it. i think that doing 1 max rep doesn't do anything for your muscles.

currently by bf is at 8% im 5'7. But hahah theres no way ill stop smoking weed just to see if ill progress faster. Maybe you're right. But fuck it, im happy gettin high and 6 weeks with no smoke would just make me cranky as fuck.

The hardest thing about my lifestyle would be dieting. But before i went to the Dominican i managed to cut down to 4%.. not bad for a stoner..



:bullshit: , do you even know what 8 percent and 4 percent look like?

civic_rida
08-30-2008, 12:38 PM
yea under 8% = pelvic and chest vascularity

pinoyhero
09-01-2008, 08:51 AM
Originally posted by Darkane


Fair enough. I'm always consciously nagged by my overactive ambitious side, so nothing is really good enough for me. But if you're happy then thats it really. Good on ya.

But yeah, as per the 4% not happening :P

http://www.t-nation.com/free_online_article/sports_body_training_performance_bodybuilding/shredded_in_6_days

Level 4 in that program is about 4-5%. Did you have lower ab vascularity? :rofl:

Haha, love shredded in 6, I try it every trip.

FilthyMcNasty
09-02-2008, 09:24 AM
Originally posted by SteveMo600


I'm with civic_rida, I call huge bullshit on the 4%. A BF level of 4% is pretty much bodybuilder's competition level. That sort of BF level is on the cusp of organ damage.

I'm not going to believe this unless more than a handful are tested, by multiple different specialists. A sample of 24 isn't even close to enough, as the sample could be incredibly skewed with people that have a hard time building muscle, different body response to exercise etc.


Heres my diet douche bags. I dieted down as if i was gonna compete. so you can all suck my balls. haha. My diet was put together by my sisters bf who won Mr. Manitoba a few years ago.



Saturday – May 30th
Do 40 minutes of morning cardio, just enough to get a sweat going. You should not be stimulating the quads doing this cardio. The only carbs you should take in today are half a cup of oats at meal one and an MRP after posing practice at 5:00 p.m. After this eat veggies and protein all day. Ie. Chicken or fish ONLY. No beef.
Again, 50mgs VS apply to both carb meals and all similar carb meals for Sunday, Monday and Tuesday. You should shop for your water, bouillon cubes, VS, diuretics, rice cakes, honey, Raisinettes (yes, the candy) and other accessories today.
If anything – we can do a light workout today only with some back + abs. That’s it.


Sunday – June 1st
This is the first stage of the carb depletion phase. Perform 40 minutes of morning cardio. After cardio, take one bouillon cube: drop it in hot water and drink. There's usually about 2000mgs of sodium in each cube, so it’s pretty strong!
Water Intake - You will get 5.5 litres of water today. You’ll use water from this total to make your bouillon drink.
Have half a cup of oats at meal one with three scoops of low or no-carb whey protein. Meal two will be flax seeds and protein, meal three beef only, and meal four flax and protein powder again.
Training - Perform a workout doing arms (3-4 sets, high reps) at 4:30 or so, and have an MRP as post-workout meal number one and half a cup of oats and chicken for post-workout meal number two. The beef should be 5-6 ounces and relatively lean. At this stage, trim excess fat away.
As far as your shakes, have 2.5 scoops of protein in each one, or about 50-55 grams of protein. Use water from your total water (see above) in the shakes. Have another bouillon cube at night, also using water from the 5.5 litres. Drink all of the water. This is very important! You want to totally flood the body with salt and water today.

Monday – June 2nd
This is the second stage of the carb depletion phase. Perform 40 minutes of morning cardio. Today you won't eat oats at meal one, just have lean beef. Have a bouillon cube with meal one using water from the 5.5 litres again. Meal two will be flax oil and protein; meal three will be beef only; and for meal four you'll have flax and protein powder again.
Your workout today is chest and shoulders (3-4 sets of each, high reps) at 6:30or so with posing to follow. Have an MRP for your post-workout meal, and one and a half cups of oats and chicken for post-workout meal number two. Again, have the bouillon cube at night.


Tuesday June 3rd
This is the third stage of the carb depletion phase. Perform 40 minutes of morning cardio. No oats at meal one, just lean beef again. Have a bouillon cube with meal one using water from the allotted 5.5 litres. Again, meal two will be flax oil and protein, meal three will be beef, and meal four will be flax and protein powder.
Your workout today is for back, traps, and calves (3-4 sets of each, high reps). Consume no post-workout carbs, just a regular low or no-carb protein shake (with no flax oil) for post-workout meal one. For post-workout meal two, have beef only. Take a bouillon cube and drink it down using water from the 5.5 litres.
Prepare chicken and sweet potatoes for the next day. You'll use fresh chicken breasts, not the frozen variety which have been drowned in sodium broth. This is one time it must be fresh!


Wednesday – June 4th
Now we enter the first stage of the no-sodium carb loading phase. Perform 40 minutes of morning cardio (last session of the program!). Water allotment today is 2.5 litres. Meals should be eaten every two hours. Drink water after, not during, each meal to avoid bloat.
Boil chicken in distilled water or bake plain and shred it up. Mix it in mashed sweet potatoes and make meals.

Alternate chicken with potato, just potato, chicken with potato, etc. for your meals. Begin at 8:00 a.m.

Your meal schedule looks like this: 8:00, 10:00, 12:00, 2:00, 4:00, 6:00, 8:00.

Take 100mgs VS with every meal. Take dandelion root and B-6 (or whatever diuretic supplement you chose) with meals one, three, and five.


Thursday – June 5th
This is the second stage of the no-sodium carb loading phase. No cardio today. Meals are every two and half hours. Water allotment today is 1.5 – 1.75 litres. Drink water after meals to avoid bloat. Chicken and sweet potato are prepared in the same manner.
Meal times are 8:00, 10:30, 1:00, 3:30, 6:00, 8:30. (6:00 and 8:30 both have chicken.)
Take diuretics at meals one, three, and five again. If you look really bloated for some reason, double them in the late afternoon and take another double dose at night before bed.
*Don’t panic though, the next day is when you really tighten up and dry out, provided you’ve been following the above instructions to the letter.*

Friday June 6th
We now enter the third stage of the no-sodium carb loading phase. Again, no cardio. Meals are every three hours. Water allotment today is 750 ml’s. (Yes, this will suck!)
Again, drink water after meals to avoid bloat. Prepare food the same way. Meal times are 7:00, 10:00, 1:00, 4:00, 7:00. Chicken is eaten at every meal.
Use discretion as to how much diuretic aid you use, and how much coffee to use in place of water to act as a diuretic. (Protein in every meal adds a diuretic effect as well.) A glass of red wine in the evening can also aid in expelling out some excess water the night before your "event," but you're not trying to get a buzz here!


Saturday June 6th

Some kind of solid, starchy carb once or twice, preferably two smaller servings. Have chicken with the first meal.
No salt.
Bring in faster acting sugars prior to your event in the car on the way or upon arriving at the event. This will bring vascularity into play and help absorb the starchy carbs into the muscles.
Take sips of water only to keep your mouth wet. Chew gum to avoid dry cottonmouth. Raisinettes and/or red wine seem to bring out vascularity quite nicely, so try one or both of these. Don’t go overboard with the Raisinettes and prepare to stun all onlookers!

The crazy thing about this, is that you will super dried out and ripped by this day.
Keep sipping on water as needed. With flying – you will get further dehydrated. By the time you get to Dominican, maybe even Toronto you will be fucking lean, and dry but vascular and full from the additional carbs.

Darkane
09-02-2008, 08:33 PM
^^ Ok so you did a modified version of Drying out. That doesn't drop you bodyfat!!

All you did was pull the water under your skin into your muscles with glycogen depletion.

Wow, clap clap.

Thanks for calling me a douchebag, I don't own a BMW.

FilthyMcNasty
09-03-2008, 08:46 AM
that was the end of my diet, my bad. Just posted to show i dieted as if i was competing. the start was 4 months of very low carb high protein dieting. theres not really much to it. its just eating small healthy portions of food with high protein low to no carbs 6 times a day.

Carlton
09-05-2008, 09:35 AM
Originally posted by JAYMEZ




:bullshit: , do you even know what 8 percent and 4 percent look like?

I saw him at 4.9% he was lean as hell.

but thanks for coming out JAYMEZZZZZ.

broken_legs
09-05-2008, 10:13 AM
I don't smoke pot anymore but in highschool I used to smoke it all the time.

The one thing I noticed that was pretty interesting was that I got a WICKED PUMP when i went to the gym high.

I wasn't interested in any sort of aerobic or endurance training but pushing big weights I noticed right away my muscles got a WICKED PUMP that lasted for hours afterwads.


That was my experience :dunno:

prae
09-05-2008, 11:06 AM
Originally posted by broken_legs
I don't smoke pot anymore but in highschool I used to smoke it all the time.

The one thing I noticed that was pretty interesting was that I got a WICKED PUMP when i went to the gym high.

I wasn't interested in any sort of aerobic or endurance training but pushing big weights I noticed right away my muscles got a WICKED PUMP that lasted for hours afterwads.


That was my experience :dunno:

probably more of a perceived 'pump' than any actual change in results...

Buffalo Soldier
09-05-2008, 11:11 AM
well working out is not only body its mind as well so even perceived pump can acheive greater results.

broken_legs
09-05-2008, 06:34 PM
Originally posted by prae


probably more of a perceived 'pump' than any actual change in results...

No

Quite literally I had a wicked pump. And it lasted long after I left the gym and long after whatever I had smoked had gone away.


Maybe you should try it ;)