For some unique shops, there is Union Street (not Square), my sis and I did a lot of damage there. LOL... They also opened up a new Science Centre it's located right in the Golden Gate Park close to the Japanese Garden. We also did the Alcatraz and Mr. Toad's Bus Tour. As for restaurants, we went to B44 and Poulf which are right in the heart of DT SF. It's one of those little alley way restaurants (I don't remember which alley though). The interesting dish that we had at B44 was the squid cooked in it's own ink. It doesn't look very appetizing, but it was actually really good. B44 is also Zagat rated.
If you have time, I would suggest a drive down to Vacaville for some Outlet shopping and maybe hit a couple of wineries while you're down that way.
Where are all the materialistic people?!