HG Motorsports in development with DeliciousTuning finally were able to tune the Lexus/Toyota ECU... product has yet to be released, but is coming out soon. Here is the first footage.
Might not sound like a feat to anyone but a Toyota/Lexus fan, but this has NEVER been achieved without piggyback's and standalone.
http://www.youtube.com/watch?v=Xt7Nb78-lZQ