b. Sucralose metabolism. The majority of ingested sucralose is excreted unchanged in the feces and most of what is absorbed appears unchanged in the urine, with only minor amounts appearing as metabolites (Refs. 3, 4, and 5). Mice (El46) and rats (El37) were found to metabolize less than 10 percent of the absorbed sucralose, while rabbits (El24) (20 to 30 percent), humans (El38 and E145) (20 to 30 percent), and dogs (El33) (30 to 40 percent) metabolize greater quantities of the absorbed sucralose. Results from the submitted animal and human pharmacokinetics data identified three major sucralose metabolites (Ml, M2, and M3) in urine in addition to unchanged sucralose.