I have a 2014 1st gen Ecoscrew and as its never really been tuned/modded, its been reliable with the exception of a rear diff issue due to being submerged and a rear main seal gasket weep.
My friend is looking for a "reasonable" half ton truck, though always tempted by the luxuries of Limited, Platinum, Laramie trims... I think he's good with a "sport" or "lariat" level kind of truck.
Talking to many people, the impressions I get are that the Tundra is bar none the most "reliable" - BUT you pay the price at the pump for having a non-modern 5.7, a 4.30 rear ratio on a larger rear end and larger brakes (rotational mass) 18/14.7 L/100km
I'm not a Ford fanboy, but a few mechanics told me that the 2.7 has been the best overall motor for reliability and tuneability, with less gremlins than any other Ford motors. (i.e. 3.5 (both gen with timing chain issues) and the 5.0 which at first had oval piston issues and now lately oil consumption problems.
I also see that the 2.7 being coupled to the 10r80 tranny and the aluminum body being maybe the best for fuel economy for most 1/2 ton owners.
I personally love the 5.7 hemi - but have been told about their lifter/ticking issues... but love their ZF tranny. Also having driven a Denali 6.2, I have to say that is also a fantastic motor, but maybe not quite a free reving as the 5.7. Does the Chevy 5.3's/6.2s have any remaining issues with its cylinder deactivation systems? - I was also told by a local shop to still get a tune deactivate it ASAP if you ever buy a new Chevy/GM.
I'm thinking that for my buddy, leasing a Lariat 502a 2.7 Ecoscrew 5.5 w/ the 4a (auto) capability is his best option for that balance of luxury, economy and practicality